The Effect Of Eating On Eating And Exercise ( Qol Ed )

The Effect Of Eating On Eating And Exercise ( Qol Ed )

Abstract

Aim: We compared the quality of life related to eating and exercise (QOL ED) in women seeking fertility treatment with and without PCOS controlling for age and BMI Body Mass Index (BMI).

Method: Twenty–one women with and 132 women without PCOS attending IVF clinics completed a questionnaire containing the QOL ED global score consisting of five eating disorder subscores.

Results: Women with PCOS had a poorer QOL ED and were almost three times more likely to obtain a score suggestive of the presence of an eating disorder (47.6%) than women without PCOS (16.7%, pWomen with PCOS are at increased risk of metabolic problems (impaired insulin resistance, impaired glucose tolerance, type 2 diabetes mellitus and cardiovascular disease),3 reproductive abnormalities (infertility, hyperandrogenism and hirsutism)4 and psychiatric illness (anxiety, depression and poorer quality of life)5,6. It is postulated that decreased fertility in women with PCOS results from ovarian hyperandrogenism, hyperinsulinemia secondary to insulin resistance and altered intraovarian paracrine signalling, which disrupt the growth of ovarian follicles. Arrested follicular development results in menstrual irregularity, polycystic ovaries, further hyperinsulinaemia and excess androgen production2,7. Anovulation is the predominant cause of infertility in PCOS8, with fewer women experiencing impaired oocyte development resulting in miscarriages9.

The optimal treatment for infertile women with PCOS is not well established. In 2011 a team of specialists developed evidence based guidelines for the assessment and management of PCOS based on current literature10. The guidelines suggest preconceptional counselling, lifestyle modifications including weight reduction and exercise, cessation of smoking, and a reduction in alcohol consumption10. After these modifications, ovulation induction with anti–estrogen clomiphenes citrate, metformin or a combination of both may be trialled10.

Approximately 50

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